2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W016011
    iBu-dG
    		99.84%
    iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    iBu-dG
  • HY-152765
    3′-Deoxy-3′-fluorouridine
    		99.66%
    3′-Deoxy-3′-fluorouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3′-Deoxy-3′-fluorouridine
  • HY-178588A
    Fluorescein-12-dUTP sodium solution (1 mM)
    Fluorescein-12-dUTP (sodium) solution (1 mM) is a fluorescent labeling and detection reagent that can be used for nucleic acid synthesis. Fluorescein-12-dUTP (sodium) solution (1 mM) can be used to synthesize labeled DNA probes for in situ hybridization, microarray or western blot analysis.
    Fluorescein-12-dUTP sodium solution (1 mM)
  • HY-B0158S1
    Cytidine-13C
    		99.0%
    Cytidine-13C is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine
    Cytidine-<sup>13</sup>C
  • HY-106777
    Cyclopentenylcytosine
    		99.76%
    Cyclopentenylcytosine (CPEC), a carbocyclic nucleoside analog of cytosine, is a potent inhibitor of CTP synthetase and causes depletion of CTP and dCTP pools. Cyclopentenylcytosine shows broad-spectrum (both DNA and RNA viruses) antiviral activity. Cyclopentenyl cytosine increases Gemcitabine (HY-17026) radiosensitisation in human pancreatic cancer cells. Cyclopentenylcytosine shows effective antiviral activity in the Ad5/NZW rabbit ocular replication model and shows anti-tumor activity in various tumor xenografts model. Cyclopentenylcytosine can be used for the study of infection and cancer.
    Cyclopentenylcytosine
  • HY-157549A
    Brivoligide sodium
    		99.37%
    Brivoligide (AYX1) sodium is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide sodium can reduce acute post-surgical pain. Brivoligide sodium mimics the DNA sequence normally bound by EGR1 on chromosomes.
    Brivoligide sodium
  • HY-B0228S9
    Adenosine-13C10,15N5
    		99.60%
    Adenosine-13C10,15N5 is the 13C and 15N labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub>
  • HY-W020098
    2'-C-methyluridine
    2'-C-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    2'-C-methyluridine
  • HY-W394106
    5-Hydroxymethyl uridine
    		≥98.0%
    5-Hydroxymethyl uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Hydroxymethyl uridine
  • HY-76693
    2,3-O-Isopropylidene-D-ribonolactone
    		99.89%
    2,3-O-Isopropylidene-D-ribonolactone is an acetonide derivative of d-ribonolactone and an intermediate in organic synthesis.2,3-O-Isopropylidene-D-ribonolactone forms via acid-catalyzed acetalization of d-ribonolactone with acetone.2,3-O-Isopropylidene-D-ribonolactone facilitates production of 1,5-dideoxy-1,5-imino-d-ribitol and 1,5-dideoxy-1,5-imino-l-arabinitol.
    2,3-O-Isopropylidene-D-ribonolactone
  • HY-113431
    Arabinosylhypoxanthine
    		99.0%
    Arabinosylhypoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine selectively inhibits viral DNA synthesis. Arabinosylhypoxanthine exhibits anti-HSV activity. Arabinosylhypoxanthine can be used in studies related to herpes simplex virus infection.
    Arabinosylhypoxanthine
  • HY-115741
    3BrB-PP1
    		99.0%
    3BrB-PP1 is an ATP-competitive analog. 3BrB-PP1 can specifically inhibit the activity of protein kinase with mutations in the ATP-binding pocket (mutation of Thr97 within Sty1’s ATP-binding pocket).
    3BrB-PP1
  • HY-113139S
    1-Methylinosine-d3
    		99.0%
    1-Methylinosine-d3 (N1-MetHYlinosine-d3) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models.
    1-Methylinosine-d<sub>3</sub>
  • HY-152702
    2,8-Dimethyladenosine
    		98.68%
    2,8-Dimethyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2,8-Dimethyladenosine
  • HY-154241
    8-Methyl-2’-deoxyadenosine
    8-Methyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Methyl-2’-deoxyadenosine
  • HY-152378
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
  • HY-152296
    8-Methyladenosine
    8-Methyladenosine is a modified adenosine nucleoside. Through methylation at the 8-position, 8-Methyladenosine confers bacterial resistance to five classes of antibiotics that bind to the ribosomal peptidyl transferase center. 8-Methyladenosine can be used in studies of antibiotic-resistant bacterial infections.
    8-Methyladenosine
  • HY-W578275
    3′-O-Methylcytidine
    		98.0%
    3′-O-Methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    3′-O-Methylcytidine
  • HY-W010706
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
    		98.86%
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA.
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
  • HY-W011079
    5-Iodouridine
    		99.93%
    5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a Ki value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia.
    5-Iodouridine